Alum-adjuvanted allergoids induce functional IgE-blocking antibodies
نویسندگان
چکیده
منابع مشابه
Depigmented Allergoids Reveal New Epitopes with Capacity to Induce IgG Blocking Antibodies
BACKGROUND The synthesis of allergen-specific blocking IgGs that interact with IgE after allergen immunotherapy (SIT) has been related to clinical efficacy. The objectives were to investigate the epitope specificity of IgG-antibodies induced by depigmented-polymerized (Dpg-Pol) allergoids and unmodified allergen extracts, and examine IgE-blocking activity of induced IgG-antibodies. METHODS Ra...
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were either unresponsive or showed elevated mRNA levels of the Th1-promoting chemokines CXCL10 and CXCL11. Conclusions: This study supported by grant SFB-F1802 of the Austrian Science Fund shows for the first time that the allergen uptake is specific and similar in DCs from allergic and healthy individuals. More important, the ensuing signal cascade that is triggered by the allergen differs bet...
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The immunogenicity and protectivity of two different toxoid vaccines were compared in mice. In one formulation, toxoids (diphtheria or tetanus) were adsorbed to alumoxid, whereas in the other formulation the toxoids were crosslinked to immunopotentiating reconstituted influenza virosomes (IRIVs). A preimmunization with influenza antigens is necessary for a good anti-toxoid antibody response whe...
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A 3-year prospective post marketing survey on the safety of the recently developed ultrashort pre-seasonal subcutaneous immunotherapy (uSCIT-MPL4) with pollen allergoids adjuvanted with monophosphoryl lipid A was performed. A total of 510 patients received uSCIT-MPL4, 61% for grass, 35.7% for birch, 13.2% for parietaria and 3% for other pollens (ragweed, mugwort, and olive). A total of 3308 inj...
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ژورنال
عنوان ژورنال: Clinical & Experimental Allergy
سال: 2018
ISSN: 0954-7894
DOI: 10.1111/cea.13120